The Newton family live in their comfortable home, but there seems to something missing. This "hole" is filled by a small puppy, who walks into their home and their lives. Beethoven, as he is named, grows into a giant of a dog... a St Bernard. Doctor Varnick, the local vet has a secret and horrible sideline, which requires lots of dogs for experiments. Beethoven is on the bad doctor's list.
One Saturday, the Slurb, a strange little creature with a proboscis nose, enters Mr. Taschenbier's life. Slurb, who immediately adopts the shy Mr. Taschenbier as his "daddy," is, however, his sheer opposite: he is cheeky and chaotic and throws his well-ordered life into sheer chaos. But when Taschenbier discovers that he can fulfill all his wishes with the help of Slurb's blue freckles, his life suddenly changes. He appeases his bad-tempered landlady, Mrs. Rotkohl, and he can finally get one over on his nasty neighbor, Mr. Lürcher. Everything could be so nice if Mr. Taschenbier didn't fall in love with his pretty colleague Mrs. März and if the Slurb didn't almost burst with jealousy...
Teenager Riley's mind headquarters is undergoing a sudden demolition to make room for something entirely unexpected: new Emotions! Joy, Sadness, Anger, Fear and Disgust, who’ve long been running a successful operation by all accounts, aren’t sure how to feel when Anxiety shows up. And it looks like she’s not alone.
When 11-year-old Riley moves to a new city, her Emotions team up to help her through the transition. Joy, Fear, Anger, Disgust and Sadness work together, but when Joy and Sadness get lost, they must journey through unfamiliar places to get back home.